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Development of the Cardiac Conduction System - No. 250
Novartis Foundation Symposium
ISBN: 0-470-85035-3 Hardcover 300 pages July 2003
The heart beats an estimated three billion times during the lifespan of the average person. Each of these cycles of contraction depends on specialized cardiac tissues involved in the rhythmic generation and coordinated spread of electrical excitation. Collectively, these tissues are known as the pacemaking and conduction system—the PCS. Since the PCS is vital for generating and synchronizing the heartbeat, its dysfunction can be a direct cause of cardiac conduction disturbance, arrhythmias and sudden cardiac death. Recent advances have meant that the cellular and molecular mechanisms governing the development of the PCS in tissues are now starting to be understood. This book brings together a group of leading researchers to discuss emerging concepts in this exciting field. In particular, the new understanding of the cellular origin and the molecular induction of PCS tissues during embryogenesis, together with the burgeoning technology of stem cell manipulation, provides the foundation for tissue engineering, replacement and repair of PCS tissues in humans. The book also identifies therapeutic targets arising from basic discoveries in the developmental biology of cardiac pacemaking and conduction tissues.


Renin Angiotensin System and the Heart
Walmor De Mello
ISBN: 0-470-86292-0 Hardcover 256 pages May 2004
Recent studies have shown that the heart possesses an intrinsic renin angiotensin system that is controlled by tissue-specific parameters that are activated by biomechanical stress. This book reviews the latest information on the way in which both the plasma and cardiac renin angiotensin systems affect heart function. It covers the cell and molecular biology of these systems, with contributions on renin synthesis, uptake and the intracellular signalling pathways. Particular insight comes from transgenic mouse models in which either mouse or human genes for various components of the renin angiotensin system are expressed. Other topics covered are wound healing as well as the trophic effects of aldosterone. Contains the most recent findings on the renin angiotensin system and the heart Written by an international team of distinguished scientists Covers both the cellular and molecular basis of the renin angiotensin system and the clinical relevance of this research


Myocardial Protection by Calcium Antagonists
Lionel H. Opie (Editor)
ISBN: 0-471-07669-4 Paperback 195 pages August 1994
There are vast amounts of new data emerging in the study of calcium antagonist drugs. The major issues involved are no longer just the effects of calcium antagonist drugs in angina or hypertension but their possible postinfarct protective effects, both to provide prophylaxis and to improve left ventricular function. New trials have also changed our thinking. One major trial suggested that the use of one of these agents in postinfarct patients with no history of heart failure in the acute infarct stage was not only safe but could confer positive protection from reinfarction and possibly from sudden death. Another study, also in postinfarct patients but with a different agent, has drawn attention to a further unexpected benefit, namely improvement of mechanical diastolic function. In the area of hypertension, the emphasis has shifted to the regression of left ventricular hypertrophy, now recognized as an independent risk factor for cardiovascular mortality, and to diastolic dysfunction. Looking to the future, calcium antagonists may exert protection against end-stage heart failure by limiting left ventricular hypertrophy and by vascular beneficial effects. There is emerging interest that the combination with ACE inhibitors may exert additive effects on control of hypertension and on diabetic hypertensive renal lesions. Reviews of Other Books by the Author Drugs for the Heart—"A gem" (New England Journal of Medicine) The Heart—"The subjects are brilliantly illuminated and made exciting by excellent line diagrams" (The Lancet) Angiotensin-Converting Enzyme Inhibitors: Scientific Basis for Clinical Use—"A milestone" (British Medical Journal)


Angiotensin-Converting Enzyme Inhibitors: Scientific Basis for Clinical Use, 2nd Edition
Lionel H. Opie
ISBN: 0-471-11195-3 Paperback 309 pages December 1994
About the Book ACE inhibitors are justly regarded as the most important advance in cardiac drug therapy since the advent of calcium channel antagonist drugs. Acting basically as inhibitors of the renin-angiotensin vasoconstrictor system, these agents have grown in importance to become among the therapeutic agents first choice for hypertension and a cornerstone of therapy in congestive heart failure. Recent studies show that they can also prevent overt heart failure and reinfarction, and beneficially influence diabetic renal lesions. The major aim of Angiotensin-Converting Enzyme Inhibitors: Scientific Basis for Clinical Use is to present the clinician with the information needed for the practical and discerning use of ACE inhibitors. When do these agents really work and in what doses? Which claims are based on promotional material and which claims have relevance for the clinician in the practical treatment of hypertension, heart failure or myocardial infarction? This Second Edition adds new material that critically reviews the recent large trials including Consensus-II, Save, V-HeFT-II, Aire, and ISIS-IV and guides the clinician toward a rational policy of use. There is an important new chapter on the use of ACE inhibitors in the metabolic cardiovascular syndrome and in diabetic nephropathy. Reviews of Other Books by the Author Drugs for the Heart—"A gem" (New England Journal of Medicine) The Heart—"The subjects are brilliantly illuminated and made exciting by excellent line diagrams" (The Lancet) Reviews of First Edition of this Book "A new milestone" (British Medical Journal) "Pathophysiology is clarified by numerous diagrams in a style well-known from Opie’s former books" (The Lancet)


Cardiac Problems in Pregnancy: Diagnosis and Management of Maternal and Fetal Heart Disease, 3rd Edition
Uri Elkayam (Editor), Norbert Gleicher (Editor)
ISBN: 0-471-16358-9 Hardcover 773 pages June 1998
Recent medical advances have made pregnancy possible for women with heart disease and saved lives. Completely revised and expanded, this latest edition of this successful and authoritative clinical guide provides step-by-step treatment methods in a clear and organized manner. Includes fifteen extensively updated chapters and offers eight new chapters on topics such as cardiopulmonary imaging, prosthetic heart valves, pregnancy after cardiac transplantation, plus the use of diuretics, vasodilators and angiotensin converting enzyme inhibitors in pregnancy.


Hemodynamic Rounds, 2nd Edition
This new edition of Hemodynamic Rounds provides an expanded series of case studies demonstrating the importance of hemodynamic measurements in understanding cardiac pathology. As with its popular predecessor, Hemodynamic Rounds, Second Edition provides numerous brief case examples incorporating different hemodynamic tracings and considers for each the factors responsible for producing those waveforms. The text is organized into chapters on specific areas of the heart, common cardiac anomalies, and hemodynamic situations resulting from different therapeutic procedures, and includes both normal and abnormal pressure waveforms. The new sections include: Mitral stenosis and pulsus alterations Low-gradient aortic valve stenosis Pitfalls of right heart hemodynamics Pulmonary balloon valvuloplasty Coronary hemodynamics for angioplasty and stenting after myocardial infarction Hemodynamic evaluation of stenotic bioprosthetic mitral valves Hemodynamic Rounds, Second Edition will be an invaluable resource for invasive cardiologists, cardiology residents, cardiac nurses, and catheterization technicians.


Myocardial Revascularization: Novel Percutaneous Approaches
The percutaneous method of transluminal myocardial revascularization has roused enthusiasm in the field of cardiology because it is minimally invasive and relatively inexpensive. In his progressive new book, George Abela, a widely recognized pioneer in cardiology and lasers, has brought together the expertise of international leaders on the subject in this premier reference, Myocardial Revascularization: Novel Percutaneous Approaches. This resource provides interventional cardiologists, technical personnel and nurses in cardiac catheterization labs with the most current scholarly and clinical information available, including: A historical overview of myocardial revascularization (including the Vineberg procedure and the more recent TMR/PMR procedures) Biological responses and mechanisms of action in myocardial revascularization using mechanical, laser, ultrasound, and cryoenergy Current technology for the percutaneous method of the procedure Descriptions of other novel approaches including percutaneous in situ coronary venous arterialization Discussion of results from preliminary and advanced TMR/PMR in canine and human procedures Examination of various catheter navigation systems and potential adjunct gene therapies Myocyte transplantation to replenish the depleted myocardium Insights into the economics of these novel percutaneous techniques


Interventional Fluoroscopy: Physics, Technology, Safety
Fluoroscopic guidance plays a central role in an increasing number of minimally invasive diagnostic and interventional procedures. Fluoroscopic apparatus and related resources continue to evolve in support of this fundamental technology. Interventional Fluoroscopy: Physics, Technology, and Safety is the first resource to provide information that the clinician needs for the safe and efficient operation of interventional fluoroscopic equipment. Topics discussed include: Basic physical and dosimetric concepts common to all forms of X-ray projection imaging systems The structure and function of key components found in the interventional fluoroscope The nature of the digital image and associated tools, such as image compression and quantitative angiography Radiation biology and radiation effects at interventional dose levels Radiation safety, including basic principles and operational and regulatory topics An introduction to vascular brachytherapy Quality assurance of interventional fluoroscopy equipment Authored by one of the most renowned experts in this field, Interventional Fluoroscopy: Physics, Technology, and Safety is an essential resource for interventional physicians, medical physicists, technologists, manufacturers, and others involved with modern interventional procedures.


Chronic Obstructive Pulmonary Disease: Pathogenesis to Treatment - No. 234
Chronic obstructive pulmonary disease (COPD) is the most common respiratory disorder of adults in the developed world and is the fourth main cause of death in the USA. It is also associated with high morbidity, and poses an enormous burden of suffering and expense. Despite this, the disease has received little attention compared with other respiratory conditions such as asthma and lung cancer. Current treatment can offer some marginal symptomatic relief but does not address the underlying disease process. Indeed, smoking cessation is the only intervention known to alter the rate of disease progression. There is clearly great need, and potential, for the development of superior therapies for symptomatic relief and disease modification. This book brings together leading researchers and physicians to discuss the most recent advances in our understanding of COPD, and draws together basic and clinical aspects relevant to the topic. Coverage includes the basic pathology, current and potential therapies, and detailed consideration of the major theories for the pathogenesis of COPD.

Congenital Heart Disease: A Diagrammatic Atlas
Comprises 167 line drawings of congenital heart defects--providing a method of reporting the results of the various cardiac imaging modalities in a detailed, anatomically realistic way, and standardizing the often confusing nomenclature. With the addition of hemodynamic data acquired during cardiac catheterization, the diagrams become accurate and concise anatomical and physiological reports. The Atlas covers many variations and combinations of atrio-ventricular, veno-atrial, and ventriculo-arterial connections; cardiac positions; atrial situs; and left and right aortic arches. Diagrams are easily modified to illustrate any abnormality by using a technique demonstrated in the book. Each diagram comes in duplicate--one labelled, to serve as a reference; and one unlabelled, to be removed, photocopied, and modified.


Geriatric Cardiology: Principles and Practice
A comprehensive review by authors of international repute regarding the management of older people with cardiovascular disease. Discusses recent initiatives leading to a much greater emphasis on the prevention of disease, quality of life aspects of management and the costs that prevention and treatment incur. Describes improvements in research techniques as well as pharmacological and surgical procedures.


A Century of Arterial Hypertension: 1896 - 1996
One hundred years ago arterial hypertension was not even mentioned in medical textbooks. In 1930 it was referred to as "a disease of civilisation". Today we know that it is largely responsible for cardiovascular deaths, the major cause of mortality in industrialised countries. Arterial hypertension is a singular disease entity. It is defined arbitrarily, it is closely linked to sociocutural factors and it has enormous economic impact. Hypertension was recognised as a risk factor between the two world wars. The driving force behind this recognition was financial rather than medical. The evolution of the understanding and management of hypertension reflects the profound changes that have affected twentieth century medicine. This book is the work of a multidisciplinary editorial team composed of internationally renowned experts. Originally published in French under the auspices of the French Society of Hypertension, this English edition has been acclaimed by the International Society of Hypertension. A Century of Arterial Hypertension reflects on the evolving concepts of hypertension over the past hundred years and reveals an essential yet little-known facet of modern medicine. The originality, wealth of historical documents and bibliography will make this book of interest not only to cardiologists and physicians in general, but to anyone who aspires to understand how modern medicine has achieved what it has.


Alcohol and Cardiovascular Disease -  No. 216
Recent years have seen a sea-change in society's attitudes towards moderate alcohol consumption with the popular view now well-established that a modest amount of alcohol, regularly ingested, will benefit health. Despite wide agreement that some degree of protection from coronary heart disease exists for certain groups who use alcohol regularly and that there are biological mechanisms which might go some way to explaining such protection, there is still some concern regarding the true magnitude of any benefit. Additional issues include the relationship of alcohol to blood pressure and cerebrovascular disease, the influence of the pattern of drinking as opposed to overall intake, the effects on ill health of changes in alcohol intake and the association of alcohol with a wide range of psychosocial factors, as well as with all-cause mortality. There is also considerable uncertainty about the effects of alcohol on the cardiovascular system in women and in the elderly and on the role that genetic factors might play. This wide-ranging book brings together an interdisciplinary group of experts working on many aspects of the biological effects of alcohol, and in particular on the cardiovascular system. It dra ws together new and exciting work in this area, reviewing an emotive subject from as dispassionate a perspective as possible. This book provides a firm basis for further research into the effects of alcohol on the cardiovascular system and into public health attitudes to what is both a universal pleasure and a problem.

Catheterization and Cardiovascular Interventions
Journal Vol 61-63 (Calendar Year 2004, 12 Issues)
Catheterization and Cardiovascular Interventions is an international journal covering the broad field of cardiovascular diseases. Subject material includes basic and clinical information that is derived from or related to invasive and interventional coronary or peripheral vascular techniques. The journal focuses on material that will be of immediate practical value to physicians providing patient care in the clinical laboratory setting. To accomplish this, the journal publishes Preliminary Reports and Work In Progress articles that complement the traditional Original Studies, Case Reports, and Comprehensive Reviews. Perspective and insight concerning controversial subjects and evolving technologies are provided regularly through Editorial Commentaries furnished by members of the Editorial Board and other experts. Articles are subject to double-blind peer review and complete editorial evaluation prior to any decision regarding acceptability.

Cardiology
by Michael H., Md. Crawford (Editor), John P. Dimarco (Editor), Walter J. Paulus (Editor), Kjell Asplund (Editor), Gerard Aurigemma (Editor), George L. Bakris (Editor), Helmut Crexler (Editor), Erling Falk (Editor), Hirohisa Kato (Editor), George J. Klein (Editor), will Kostuk
Hardcover: 1728 pages ; Dimensions (in inches): 2.55 x 11.75 x 10.25
Publisher: Mosby; 2nd Book and CD-ROM edition (December 2003)

Cardiac Surgery (2 Volume Set)
by Nicholas Kouchoukos (Editor), Eugene Blackstone, Donald Doty, Frank Hanley, Robert Karp.
Publisher: W B Saunders; Third edition (July 31, 2003) Comprehensive two-volume set describes and illustrates the latest in cardiac surgical procedures. Includes new material on managing endocarditis and diseases of pulmonary arteries and systemic veins. Previous edition: c1993. DNLM: Cardiac Surgical Procedures--methods.

Textbook of Interventional Cardiology
Fifty-three contributions provide up-to- date, clinically-oriented coverage of the latest techniques, devices, and adjunctive therapies related to percutaneous coronary revascularization, as well as critiques of emerging therapeutic approaches. In this edition, there is new or expanded coverage of drug-coated stents, inflammation and arterial injury, angiogenesis, percutaneous bypass surgery, device genomics, hypertrophic cardiomyopathy, stem cell therapy for ischemic heart disease, prophylactic aspirin use, detection of vulnerable plaque, the amplified impact of non-coronary interventions, improvements in adjunctive pharmacotherapy, and current material on congenital heart disease and restenosis. Illustrated with color and b&w images. Edited by Eric J. Topol of The Cleveland Clinic Foundation.

Vascular and Interventional Radiology: The Requisites

Practical Approach to Cardiac Anesthesia

Pathophysiology of Heart Disease: A Collaborative Project of Medical Students and Faculty

Textbook of Clinical Echocardiography

The Practice of Clinical Echocardiography

Heart Disease: A Textbook of Cardiovascular Medicine (2-Volume Set)

Sclerotherapy: Treatment of Vericose and Telangiectatic Leg Veins

Cardiac Pacing and Defibrillation: A Clinical Approach

Mayo Clinic Cardiology Review

Proteomic and Genomic Analysis of Cardiovascular Disease

A Practical Atlas of Congenital Heart Disease

Valvular Heart Disease

Cardiac Anesthesia

Textbook of Cardiovascular Medicine (Book with CD-ROM)

Surgery of the Aorta and Its Branches

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